• Radisky D, Muschler J, Bissell MJ. Order and Disorder: The Role of Extracellular Matrix in Epithelial Cancer. Cancer investigation. 2002;20(1):139-153.

  • Rissell MJ, Hall HG, Parry G. How Does Extracellular Matrix Direct Gene Expression? J Theor Biol. 1982;99(1):31–68

  •  Howe A, Aplin AE, Alahari SK, Juliano RL. Integrin Signaling and Cell Growth Control. Curr Opin Cell Biol. 1998;10(2):220–231

  • De Archangelis A, Georges-Labouesse E. Integrin and ECM Functions: Roles in Vertebrate Development. Trends Genet. 2000;16(9):389–395.


  • Streuli C. Extracellular Matrix Remodeling and Cellular Differentiation. Curr Opin Cell Biol. 1999;11(5):634–640. 

  • Jones FS, Jones PL. The Tenascin Family of ECM Glycoproteins: Structure, Function, and Regulation During Embryonic Development and Tissue Remodeling. Dev Dyn. 2000;218(2):235–259. 

Licensed Cripto-1 Patents, NIH License Number L-282-2014/0

  • U.S. Patent No. 7,078,176
  • PCT Application No. PCT/US02/02225
  • U.S. Provisional Patent Application No. 60/264,643
  • Canadian Patent No. 2,434,694
  • Australian Patent No. 2002236871
  • Europe Patent No. 1370869 (Validated in Germany, France, Italy, Spain, Ireland, Great Britain, Switzerland)
  • Japan Patent No. 3821779


  • Caterina Bianco, Luigi Strizzi, Mario Mancino, Kazuhide Wantanabe, Monica Gonzales, Shin Hamada, David S. Salomon, et al,Regulation of Cripto-1 Signaling and Biological Activity by Caveolin-1 in Mammary Epithelial Cells


  • Kazhuhide Wantanabe, Shin Hamada, Caterina Bianco, Mario Mancino, Tadahiro Nagaoka, Monica Gonzales, Luigi Strizzi, David S. Salomon, Mechanism of Signal Transduction: Requirement of Glycosylphosphatidylinositol Anchor of Cripto-1 for trans Activity as a Nodal Co-receptor


  • Su B-B, Shi H, Wan J.Role of serum carcinoembryonic antigen in thedetection of colorectal cancer before and after surgical resection. World Journal of Gastroenterology : WJG. 2012;18(17):2121-2126. doi:10.3748/wjg.v18.i17.2121.

  • Locker GY, Hamilton S, Harris J, Jessup JM, Kemeny N, Macdonald JS, Somerfield MR, Hayes DF, Bast RC. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol. 2006;24:5313–5327. [PubMed]

  • Duffy MJ, van Dalen A, Haglund C, Hansson L, Holinski-Feder E, Klapdor R, Lamerz R, Peltomaki P, Sturgeon C, Topolcan O. Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. Eur J Cancer. 2007;43:1348–1360. 

  • Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965;121:439–462

  • Pignatelli M, Durbin H, Bodmer WF.Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions. Proc Natl Acad Sci USA. 1990;87:1541–1545. 


Cripto-1 Intellectual Property

Published Literature - Abbreviated List

Easy, Accurate and Affordable Cancer Screening....Welcome to the Beacon Revolution!